As a season pass holder at Loon for years, I've had plenty of experience fighting the weekend crowds. However, once you get the hang of it, you can get quite a few runs in with minimal line waiting. Here's how:
1) Show up early and catch the gondola up. Do not return to the gondola after this! The lines at the Gondola are far too crowded --more so than any other lift! From the gondola Ski down to the North Peak Quad (the lift farthest to the East).
2) Do several runs looping back to the North Peak Quad until around 11:00am. (There's plenty of ways to do it, so you won't get bored.) By that time the North Peak Quad lines start getting too long, so you'll want to avoid it for a couple hours. You can, however, sneak a run or two in on the East Basin Double (which runs close by the North Peak Quad but slightly westward). By around 11:30 the double will be packed too --so you should avoid it.
3) By 12;00pm work your way over to the Kanc Quad. It seems around lunch time that the crowds on the mountain tend to thin right to left (if you're facing up hill). Therefore, you can sneak a few runs in on the Kanc Quad (the lift farthest to the West) for an hour or so without running into any crazy lines.
4) By around 1:00pm everyone returns from lunch so the place gets packed again. There's no avoiding lines at this time. However, skiiers tend to drop like flies at this point. I think it has something to do with the beer at lunch kicking in.
5) By around 2:00pm the lines at the East basin have dwindled and you should consider the North Peak Quad and East Basin Double open for business again.
6) By 3:00pm the lift lines disappear completely and you can work just about any lift you want without a wait.
Hope this helps.